Top 4 Erectile Dysfunction Medications to Treat Ed

Erectile Dysfunction Medications

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Erectile dysfunction (ED) is a common issue affecting millions of men worldwide. It can cause significant stress and impact relationships, but fortunately, effective medications are available to help manage this condition. This article delves into the top four Erectile Dysfunction Medications: Avanafil (Stendra), Sildenafil (Viagra), Tadalafil (Cialis), and Vardenafil, providing comprehensive details on each.

What is Erectile Dysfunction Medication?

Erectile dysfunction medications are prescription drugs designed to help men achieve and maintain an erection sufficient for sexual intercourse. These medications typically work by enhancing the effects of nitric oxide, a natural chemical the body produces to relax muscles in the penis, increasing blood flow.

How Erectile Dysfunction Medications Work

ED medications belong to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. These drugs inhibit the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP). This results in the relaxation of smooth muscle cells and increased blood flow to the penis, facilitating an erection when sexually stimulated.

Avanafil (Stendra)


Avanafil, sold under the brand name Stendra, is a newer PDE5 inhibitor approved for the treatment of ED. It is known for its rapid onset of action.

Dosage and Administration

Avanafil is typically taken 15-30 minutes before sexual activity. The starting dose is usually 100 mg, but it can be adjusted based on efficacy and tolerance.


  • Quick onset: Effects can be felt as soon as 15 minutes after taking the medication.
  • Short duration of side effects: Side effects tend to be less prolonged compared to other ED medications.

Side Effects

Common side effects include headache, flushing, nasal congestion, and back pain. These side effects are generally mild and transient.


Avanafil can be purchased through various pharmacies, including GoodRx-Gold Pharmacy, which offers competitive pricing and discounts.

Sildenafil (Viagra)


Sildenafil, marketed as Viagra, is one of the most well-known and widely used ED medications. It was the first PDE5 inhibitor approved for ED treatment.

Dosage and Administration

Sildenafil is usually taken 30-60 minutes before sexual activity. The recommended starting dose is 50 mg, which can be adjusted based on response and tolerability.


  • Proven efficacy: Extensively studied and has a high success rate in treating ED.
  • Well-known: Long history of use with extensive patient experience.

Side Effects

Side effects may include headache, flushing, indigestion, nasal congestion, dizziness, and visual disturbances. Most side effects are temporary and manageable.


Sildenafil is available at most pharmacies, including GoodRx-Gold Pharmacy, where patients can find discounts and affordable options.

Tadalafil (Cialis)


Tadalafil, known by the brand name Cialis, is another popular ED medication. It is noted for its long duration of action.

Dosage and Administration

Tadalafil can be taken as needed before sexual activity or as a daily dose. The as-needed dose is usually 10 mg, while the daily dose is typically 2.5 mg to 5 mg.


  • Long duration: Effects can last up to 36 hours, earning it the nickname “the weekend pill.”
  • Flexibility: Available in both on-demand and daily dosing options.

Side Effects

Common side effects include headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually diminish over time.


Tadalafil is readily available at GoodRx-Gold Pharmacy, which provides significant savings and accessibility for patients.



Vardenafil, sold under the brand name Levitra, is another effective PDE5 inhibitor used for treating ED.

Dosage and Administration

Vardenafil is usually taken about 60 minutes before sexual activity. The typical starting dose is 10 mg, adjustable based on efficacy and side effects.


  • Effective: Proven to help achieve and maintain an erection in many men.
  • Selective action: Slightly more selective for PDE5, which may reduce the likelihood of side effects related to other PDEs.

Side Effects

Possible side effects include headache, flushing, nasal congestion, indigestion, and dizziness. These side effects are usually mild and temporary.


Vardenafil is available through GoodRx-Gold Pharmacy, where patients can benefit from reduced prices and convenience.

Comparing Erectile Dysfunction Medications

Onset and Duration

How long they last

Side Effects

While all these medications share common side effects like headaches and flushing, the severity and duration can vary. Tadalafil is known for muscle aches, whereas Sildenafil and Vardenafil might cause visual disturbances.

Dosage Flexibility

Tadalafil offers the most flexible dosing with both daily and as-needed options, while the others are primarily taken as needed.


What is the best time to take erectile dysfunction medication?

The best time to take ED medication depends on the specific drug. Avanafil is taken 15-30 minutes before sexual activity, Sildenafil 30-60 minutes prior, Tadalafil can be taken daily or 30-45 minutes before activity, and Vardenafil about 60 minutes beforehand.

Can I take erectile dysfunction medication with food?

Sildenafil and Vardenafil may be less effective if taken with a high-fat meal. Avanafil and Tadalafil are less affected by food, but it’s best to follow specific instructions for each medication.

Are there any serious side effects of erectile dysfunction medications?

Serious side effects are rare but can include prolonged erections (priapism), sudden vision loss, and hearing loss. If any severe side effects occur, seek medical attention immediately.

Can I buy erectile dysfunction medication online?

Yes, ED medications can be purchased online from reputable pharmacies such as GoodRx-Gold Pharmacy. It’s important to ensure you are buying from a legitimate source to avoid counterfeit products.

How do I know which erectile dysfunction medication is right for me?

The best ED medication for you depends on various factors, including your health, the severity of your ED, and how you respond to the medication. Consulting with a healthcare provider is essential to determine the most suitable option.

Do erectile dysfunction medications work for everyone?

ED medications are effective for many men but not everyone. If one medication doesn’t work, another might, and other treatments are available for those who do not respond to PDE5 inhibitors.


Choosing the right erectile dysfunction medication involves understanding the differences between Avanafil (Stendra), Sildenafil (Viagra), Tadalafil (Cialis), and Vardenafil. Each has unique benefits, onset times, durations, and potential side effects. Consult with your healthcare provider to determine which medication suits your needs best. GoodRx-Gold Pharmacy offers these medications at competitive prices, making treatment more accessible and affordable.

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